Forums > General Discussion   Shooting the breeze...

why do you care

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Created by CH3MTR4IL5 > 9 months ago, 12 Feb 2024
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fangman
WA, 1906 posts
14 Mar 2024 6:04PM
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Flying Dutchman said..

fangman said..


1)B
2)C
3)B
4)IL-7(There's two 'C's)
5)A
6)A


haha! Well played.

Flying Dutchman
WA, 1731 posts
14 Mar 2024 6:53PM
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fangman said..



Flying Dutchman said..




fangman said..





1)B
2)C
3)B
4)IL-7(There's two 'C's)
5)A
6)A





haha! Well played.

We're friends again

remery
WA, 3709 posts
14 Mar 2024 7:20PM
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Pcdefender said..
Some interesting lyrics....

[Verse 1]
Psychic spies from China try to steal your mind's elation
And little girls from Sweden dream of silver-screen quotation
And if you want these kind of dreams, it's Californication

[Verse 2]
It's the edge of the world and all of Western civilization
The sun may rise in the East, at least it settled in a final location
It's understood that Hollywood sells Californication

[Pre-Chorus]
Pay your surgeon very well to break the spell of aging
Celebrity skin: is this your chin or is that war you're waging?
First born unicorn
Hardcore soft porn

[Chorus]
Dream of Californication
Dream of Californication

[Verse 3]
Marry me, girl, be my fairy to the world, be my very own constellation
A teenage bride with a baby inside getting high on information
And buy me a star on the boulevard, it's Californication

[Verse 4]
Space may be the final frontier but it's made in a Hollywood basement
And Cobain, can you hear the spheres singing songs off Station to Station??
And Alderaan's not far away, it's Californication



This is mind blowing. : r/conspiracy_commons (reddit.com)


Which part is interesting?

Personally I like these lyrics:

But what a fool believes, he sees
No wise man has the power to reason away
What seems to be
Is always better than nothing

remery
WA, 3709 posts
14 Mar 2024 7:27PM
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Flying Dutchman said..

Farken hell since when did doing your own research become a negative?

Don't research anything, just do what you're told, that's a good boy.


I've decided doing my own research on board shaping is the future. How hard can it be, I just Googled "board shaping" and got 262,000,000 results in 0.32 seconds.

remery
WA, 3709 posts
14 Mar 2024 7:34PM
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Flying Dutchman said..

1)B
2)C
3)B
4)IL-7(There's two 'C's)
5)A
6)A



Nice work. Can you elaborate on how it is that there are "several cell types expressing IL-7 receptors including not only T cells but also ILC, T cells, M1/M2 monocytes, DCs, eosinophils, and neutrophils. When IL-7 is administered through subcutaneous or intramuscular route, various skin-related side effects can occur due to the response of skin-resident ILC or T cells to IL-7. Changing the administration route to intravenous injection can help address these issues. Alternatively, developing an immunocytokine with targeting moiety to T cell such as anti-CD3, -CD4, or -CD8 that selectively activates IL-7 in T cells through 'cis-acting' could be another viable option, reducing the activation in non-target cells."?

Flying Dutchman
WA, 1731 posts
14 Mar 2024 10:16PM
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remery said..


Flying Dutchman said..

1)B
2)C
3)B
4)IL-7(There's two 'C's)
5)A
6)A





Nice work. Can you elaborate on how it is that there are "several cell types expressing IL-7 receptors including not only T cells but also ILC, T cells, M1/M2 monocytes, DCs, eosinophils, and neutrophils. When IL-7 is administered through subcutaneous or intramuscular route, various skin-related side effects can occur due to the response of skin-resident ILC or T cells to IL-7. Changing the administration route to intravenous injection can help address these issues. Alternatively, developing an immunocytokine with targeting moiety to T cell such as anti-CD3, -CD4, or -CD8 that selectively activates IL-7 in T cells through 'cis-acting' could be another viable option, reducing the activation in non-target cells."?

Thanks ChatGPT 3.5


IL-7 Receptors
: Interleukin-7 (IL-7) is a cytokine involved in regulating the immune system. It acts by binding to IL-7 receptors present on the surface of various immune cells. These receptors are not exclusive to T cells; they are also expressed on other immune cell types such as innate lymphoid cells (ILCs), monocytes (including M1/M2 subsets), dendritic cells (DCs), eosinophils, and neutrophils.

Administration Routes and Side Effects: When IL-7 is administered through subcutaneous or intramuscular routes, it can lead to skin-related side effects. This is likely due to the response of immune cells residing in the skin, such as ILCs or T cells, to the IL-7 stimulus.

Intravenous Injection: Changing the administration route to intravenous injection can potentially mitigate these skin-related side effects. This is because intravenous delivery allows for more direct and uniform distribution of IL-7 throughout the body, potentially reducing the localized response in the skin.

Immunocytokine Approach: Another approach involves developing an immunocytokine, which is a fusion protein combining a cytokine (in this case, IL-7) with an antibody fragment that specifically targets certain immune cells. In this scenario, the targeting moiety of the immunocytokine would be directed towards T cells, utilizing antibodies against T cell surface markers such as CD3, CD4, or CD8. By selectively activating IL-7 only in T cells through a mechanism known as "cis-acting," the activation of IL-7 in non-target cells could be minimized. This targeted approach aims to enhance the therapeutic effects of IL-7 while reducing potential side effects associated with its non-specific activation in various immune cell types.

In summary, the provided information outlines different strategies to modulate the effects of IL-7 in the immune system, considering its diverse receptor expression and potential side effects upon administration. These strategies include altering the route of administration and developing targeted immunocytokines to selectively activate IL-7 in specific immune cell populations.

remery
WA, 3709 posts
14 Mar 2024 10:30PM
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So I assume that, having done your own "research", you are embracing the finding that "cancer vaccines may be a promising approach for effectively applying IL-7 in cancer immunotherapy?"

D3
WA, 1506 posts
14 Mar 2024 11:40PM
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Pcdefender said..


Another brilliant post.

Cleverly identifying that while masks are useless at filtering out droplets containing viral particles, they are somehow able to filter out O2.

D3
WA, 1506 posts
14 Mar 2024 11:43PM
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Well I'm not surprised you'd think that of him.
He's made a lot of money, hard to do that if you're stupid.

But he's one of those people who would prefer to believe a survey or an opinion piece over actual scientific evidence.

D3
WA, 1506 posts
14 Mar 2024 11:48PM
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Pcdefender said..

D3 said..


I'm assuming you follow the science of Steve Kirsch?



Here he is speaking in the first few minutes.

The Game Continues - Their Prize Is Your Soul (odysee.com)


You listen or watch his Debate against Avi.

He still hasn't payed up his wager

D3
WA, 1506 posts
14 Mar 2024 11:52PM
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Flying Dutchman said..

fangman said..


1)B
2)C
3)B
4)IL-7(There's two 'C's)
5)A
6)A


Well done, now please show your working.

As in, did you actually know this from the vast amount of time you have spent researching the topic?

Or did you just look up the answers or ask Reddit?

myscreenname
2284 posts
15 Mar 2024 5:53AM
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Flying Dutchman said..
Thanks ChatGPT 3.5

That would have been my go to also. The power of the technology astounds and frightens me. I think the technology will either destroy us or turn earth into a paradise.

ChatGTP has improved a lot since it was released to the public a bit over a year ago. The newest version earned a score of 297 in the Uniform Bar Examination, placing it in the top 10% of all students.


www.abajournal.com/web/article/latest-version-of-chatgpt-aces-the-bar-exam-with-score-in-90th-percentile

psychojoe
WA, 2237 posts
15 Mar 2024 5:54AM
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remery said..

Flying Dutchman said..

1)B
2)C
3)B
4)IL-7(There's two 'C's)
5)A
6)A




Nice work. Can you elaborate on how it is that there are "several cell types expressing IL-7 receptors including not only T cells but also ILC, T cells, M1/M2 monocytes, DCs, eosinophils, and neutrophils. When IL-7 is administered through subcutaneous or intramuscular route, various skin-related side effects can occur due to the response of skin-resident ILC or T cells to IL-7. Changing the administration route to intravenous injection can help address these issues. Alternatively, developing an immunocytokine with targeting moiety to T cell such as anti-CD3, -CD4, or -CD8 that selectively activates IL-7 in T cells through 'cis-acting' could be another viable option, reducing the activation in non-target cells."?


That's great. Do you have a phD? or do you bring nothing to the table like the rest of us.

myscreenname
2284 posts
15 Mar 2024 6:21AM
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remery said..
Nice work. Can you elaborate on how it is that there are "several cell types expressing IL-7 receptors including not only T cells but also ILC, T cells, M1/M2 monocytes, DCs, eosinophils, and neutrophils. When IL-7 is administered through subcutaneous or intramuscular route, various skin-related side effects can occur due to the response of skin-resident ILC or T cells to IL-7. Changing the administration route to intravenous injection can help address these issues. Alternatively, developing an immunocytokine with targeting moiety to T cell such as anti-CD3, -CD4, or -CD8 that selectively activates IL-7 in T cells through 'cis-acting' could be another viable option, reducing the activation in non-target cells."?


How did you know all this and how is it you know vax boy was correct?

fangman
WA, 1906 posts
15 Mar 2024 6:26AM
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Pcdefender posted a meme that deserved a triple facepalm;


Imagine lying on the operating table in a hospital knowing that the surgeon, assistants, and nurses and anaesthetist are all so oxygen deprived that they should leave the operating theatre. Yikes!


fangman
WA, 1906 posts
15 Mar 2024 7:47AM
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Flying Dutchman
WA, 1731 posts
15 Mar 2024 9:07AM
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D3 said..
Well done, now please show your working.

As in, did you actually know this from the vast amount of time you have spent researching the topic?

Or did you just look up the answers or ask Reddit?

I just did my own research.

Mr Milk
NSW, 3115 posts
15 Mar 2024 12:12PM
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myscreenname said..

ChatGTP has improved a lot since it was released to the public a bit over a year ago. The newest version earned a score of 297 in the Uniform Bar Examination, placing it in the top 10% of all students.

But if you ask it a windsurfing question, it still just grabs an answer off Seabreeze. Which is probably due to the resident population of genii.

remery
WA, 3709 posts
15 Mar 2024 2:42PM
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Flying Dutchman said..

I just did my own research.


Data is not information, information is not knowledge, knowledge is not understanding, understanding is not wisdom. - Clifford Stoll

Flying Dutchman
WA, 1731 posts
15 Mar 2024 4:06PM
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remery said..
Data is not information, information is not knowledge, knowledge is not understanding, understanding is not wisdom. - Clifford Stoll

Long Covid is not Long Covid anymore apparently.

www.theguardian.com/society/2024/mar/15/long-covid-symptoms-flu-cold

remery
WA, 3709 posts
15 Mar 2024 4:53PM
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"The researchers acknowledged the findings are associations and do not represent prevalence, and acknowledged limitations in that participants who attended hospital or had pre-existing illness were not identifiable.

They also said because 90% of people in Queensland were vaccinated when Omicron emerged, the lower severity of long Covid could be due to vaccination and the variant.
...
Prof Jeremy Nicholson, the director of the Australian National Phenome Centre at Murdoch University, said the question of whether long Covid is unique "cannot be simply answered in this work".

"The study is observational, based on reported symptoms with no physiological or detailed functional follow-up data. Without laboratory pathophysiological assessment of individual patients, it is impossible to say that this is indistinguishable from flu-related or any other post-viral syndrome," Nicholson said."

D3
WA, 1506 posts
15 Mar 2024 5:52PM
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Flying Dutchman said..

D3 said..
Well done, now please show your working.

As in, did you actually know this from the vast amount of time you have spent researching the topic?

Or did you just look up the answers or ask Reddit?


I just did my own research.


Please feel free to utilise the same methods and tools to research Covid19, Covid19 vaccine safety and the effectiveness of treatments such as Ivermectin for Covid19.

remery
WA, 3709 posts
15 Mar 2024 7:08PM
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Sadly ignorant Australians are easily manipulated by conservative US media (laughingly dominated by an Australian billionaire), hence all the embarrassing, lame and irrelevant Seabreeze memes about Obama, Trump, Biden.

Anyway, this graph highlights the covid death rate among poorly educated conservative folk. Perhaps this is a good thing for the future of humanity.


Carantoc
WA, 7188 posts
16 Mar 2024 1:52PM
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^
So, the rate of deaths with covid# had the same trajectory when vaccines were available as to when they weren't ?

Interesting.


# Sorry, "death rates from Covid-19"## as the headline puts it

##Sorry, checked again, "Covid-related deaths" as the small-print puts it.


meh, yeah, I'll keep reading it as non-tramatic deaths within 30 days of a covid-19 positive test.

Carantoc
WA, 7188 posts
16 Mar 2024 2:01PM
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www.abc.net.au/news/2024-03-15/long-covid-symptoms-queensland-chief-health-officer-john-gerrard/103587836

.John Gerrard said the description wrongly implied long-term post-COVID viral symptoms were "somehow unique and exceptional" to other viral infections, but new research suggested they were indistinguishable.


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remery said..
...Prof Jeremy Nicholson, the director of the Australian National Phenome Centre at Murdoch University, said the question of whether long Covid is unique "cannot be simply answered in this work".

"The study is observational, based on reported symptoms with no physiological or detailed functional follow-up data. Without laboratory pathophysiological assessment of individual patients, it is impossible to say that this is indistinguishable from flu-related or any other post-viral syndrome," Nicholson said."



So - you are suggesting the Queensland Chief Health Officer isn't following the best advice and is running with some observational and anecdotal information to make decisions about what the politcal response to Covid should be ?.

mmmm interesting.

Just so I can do my own research, could you confirm (via empirical scientic methods)...

When somebody suggests the Chief Health Officer might not be following the best advice and is running with some observational and anecdotal information to manage Covid-19, does it make a difference who is making the suggestion this may be occuring, or is the viability of the accusation only dependant on remery's view of the world and whether the basis of accusation reinforces or hinders that view ?

remery
WA, 3709 posts
16 Mar 2024 5:50PM
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So - you are suggesting that I am suggesting something. I'm just quoting the news.

Tequila !
WA, 1028 posts
16 Mar 2024 5:56PM
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remery said..
Sadly ignorant Australians are easily manipulated by conservative US media (laughingly dominated by an Australian billionaire), hence all the embarrassing, lame and irrelevant Seabreeze memes about Obama, Trump, Biden.

Anyway, this graph highlights the covid death rate among poorly educated conservative folk. Perhaps this is a good thing for the future of humanity.



Haha...if you post a meme of my fanboys you die of Covid

The wedgies you took while at primary school +plus the kick me stickers on your back did result in something, we can tell.

Carantoc
WA, 7188 posts
16 Mar 2024 6:40PM
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remery said..
So - you are suggesting that I am suggesting something. I'm just quoting the news.


Are you are suggesting that I am suggesting you suggested something ?

I am just asking a question. Did you read my question as an implication ?

How come you only ever quote one side of the news ? I'd have thunk your scientific methods would make you quote all sides equally. Why is my thinking wrong ?

fangman
WA, 1906 posts
16 Mar 2024 9:07PM
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Woohoo not many weeks away until,




CH3MTR4IL5
WA, 938 posts
17 Mar 2024 8:09AM
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it may be many years away, but there's going to come a day when one of you starts a covid diatribe and an unsuspecting kid is going to say "what's a covid?", before their parents shoo them away.

that's a long way of quoting the Disney classic. let it go.



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Forums > General Discussion   Shooting the breeze...


"why do you care" started by CH3MTR4IL5